002: Getting To The Root Of SIBO w/ Dr. Mark Pimentel

SIBO, or Small Intestine Bacterial Overgrowth, is a condition where the good bacteria that grows in other parts of the gut migrate to the small intestine where it’s not supposed to be.

You’ll have symptoms of bloating, stomach pain, cramps, and, of course, gas.

The condition affects close to 60 million people across the United States, and guest, Dr. Mark Pimentel, and I have been chatting over the past year about what causes SIBO and how you can treat it.


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About Dr. Mark Pimentel

Dr. Mark Pimentel is the head of the Pimentel Laboratory and the Executive Director of the Medically Associated Science and Technology (MAST) program at Cedars-Sinai Medical Center.

A leading specialist in studying the causes of SIBO, IBS (Irritable Bowel Syndrome), and other microbiome related diseases, Dr. Pimentel has been instrumental in delivering treatments, tests, and classifications of these gut diseases.

Dr. Pimentel believes that a SIBO diagnosis is often overused as it can be a catch-all for many different types of GI disorders and that it’s important to get to the root cause of the issue before starting treatment.

We talk about why your tummy makes noise, even when you’re not hungry and why you should probably be avoiding lactose in your diet. We look at the correlation between SIBO and other gut issues with certain vitamins, minerals, and gasses in the body.

Do you suffer from bloating, especially after a meal? Is there a history of SIBO or other gut-related diseases in your family? Do you supplement with a daily probiotic?

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In This Episode

  • What some of the conditions that cause SIBO are
  • Why your tummy makes noise when you’re not hungry and what the migrating motor complex is
  • Why people with SIBO should steer clear of dairy products
  • What the relationship between SIBO, bacteria, and folate (iron) is
  • How methane contributes to weight gain and weight loss prevention
  • How you can incorporate probiotics in your diet when you have SIBO


“My job is to prove that you don’t have SIBO first but if you do, then we need to prove why you have SIBO.” (3:24)

“The association between IBS and SIBO is clear. I’d say that probably 70% of IBS is SIBO.” (5:26)

“No human on the planet can drink a gallon of milk without getting bloated, because we only have so much enzyme to break down the lactose.” (9:17)

“You have various layers of protection against the outside world. So your skin on the outside of your body is very non-permeable to ward off infections. However, the gut is very special because you want it to absorb things… but not everything, such as certain toxins or some patients have multiple chemical sensitivities.” (24:05)


Enroll for the latest Masterclass with Dr. Mark Pimentel, titled Cutting Edge Research

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3 thoughts on “002: Getting To The Root Of SIBO w/ Dr. Mark Pimentel”

  1. Can folate cause constipation and the IBS symptoms have returned ?
    I have MTHFR and got folate I started getting constipated and now my IBS symptoms are back and severely constipated
    I had control my symptoms with diet .!

    1. Funny you say this folate
      Constipated me as well .
      My Dr laughed at me she doesn’t believe me . I have MTHFR as well.
      I actually was very sick from constipation . I removed it but have to magnesium now .

      1. Oh boy, I’m sorry you got laughed at by your doctor! But I’m glad you have things under control! Always trust your gut over any practitioner’s advice! I’m glad to hear though you have that constipation under control. But I hope you’re getting more mindful care now because having a practitioner onboard can be such a game-changer too!

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